As industrial and automotive systems grow more connected, ISACLAB researches how to detect and mitigate cyberattacks, sensor faults, and anomalies before they compromise safety. We design secure control and sensor-fusion strategies for industrial gas turbines, and deep-learning-based intrusion detection and fault-tolerant cruise control for connected and autonomous vehicles, addressing actuator lag, communication delay, and adversarial sensor manipulation. This research has appeared in IEEE Transactions on Industrial Cyber-Physical Systems and IEEE Sensors Journal, often with international collaborators.